The Breakthrough Prize honors those at the forefront of the fundamental physics, life sciences and mathematics fields, and will honor the recipient of the inaugural Breakthrough Junior Challenge. Breakthrough Prize Founders and Silicon Valley innovators Sergey Brin (Google) and Anne Wojcicki (23andMe), Jack Ma (Alibaba) and Cathy Zhang, Yuri Milner (DST Global) and Julia Milner, and Mark Zuckerberg (Facebook) and Priscilla Chan will present the Breakthrough Prize Ceremony, along with Vanity Fair editor Graydon Carter. Expected celebrity guests include: host Seth McFarlane, musical performer Pharrell Williams, and presenters Russell Crowe, Hilary Swank, Lily Collins, and Thomas Middleditch and Martin Starr of HBO’s Silicon.